We Also Provide Services LikeRead More
Discovery Chemistry
Discovery Chemistry
Mavens has a cutting-edge infrastructure and a seasoned team of specialists with experience in a variety of therapeutic areas and target groups.
From target validation to clinical candidacy, we provide high-quality and cost-effective discovery chemical services, as well as extensive molecular modelling support. These services are available on a full-time-equivalent basis as well as on a fee-for-service basis. Hit and lead identification is followed by candidate optimization, with process and scale-up chemistry thrown in for good measure. As part of lead optimization, the discovery chemistry is also offered in conjunction with discovery biology services, all with the goal of identifying clinical candidates.
Individual client projects are assigned dedicated people and access-controlled labs, and a linear FTE model is followed. We serve clients from the beginning stages of discovery all the way up to GMP synthesis of the lead candidate for clinical studies and commercial batches, with the potential to scale up from milligramme to multi-kilogram amounts.
Mavens has a track record of providing our partners/clients with optimised leads and clinical candidates ahead of schedule. Patents, papers, and posters created over decades illustrate Mavens’ inventiveness and innovation.
Chemistry Services:
A group of 100 highly skilled scientists has collaborated with clients all around the world, employing cutting-edge technology to provide them with efficient synthesis and delivery of a concentrated library of substances.
Synthesis Services:
We have a 4-year track record of providing high-quality organic synthesis knowledge ranging from milligrammes to multigrams.
Expertise in a variety of compound classes, including as heterocyclic and non-heterocyclic drug-like small molecules, peptides, natural products, carbohydrates, prodrugs (phosphate/non-phosphate), nucleosides, and PROTACs, among others.
Libraries synthesis capabilities that are tailored to your needs and focused on Hit to Lead.
Medicinal Chemistry:
Our unique medicinal chemistry services provide you the flexibility to outsource medicinal chemistry alone or in conjunction with discovery biology (in vitro potency and selectivity assays; Tier I, II, and III ADME assays; and numerous efficacy models) based on your needs. Expert guidance on programme beginning points, methods, and target validation is available for early programmes. We have the added benefit of being able to transfer knowledge more easily because the Chemistry and Biology teams are located on the same location.
- Knowledge-based and in silico / CADD-based approaches are used to identify hits. Both of these methods can be used at the same time.
- Hit for the Lead: Focused NCEs for determining SAR quickly, as well as early assessment of ADME and physiochemical properties
- Optimisation of leads: Potency, selectivity, pharmacodynamics, or target engagement assay optimization with intended or agreed-upon ED50 criteria
- Nominations for candidates: Compound(s) scale-up for candidate enabling investigations
- Expertise in a variety of therapeutic illness areas, including Oncology, Metabolics, Inflammation, CNS, Neglected Diseases, and Gastrointestinal Diseases, among others.
- Assistance with the filing of a provisional patent application.
- Mini-block parallel synthesis, combiflash, microwave initiator, freeze dryer, and autoclaves are all available in dedicated synthetic labs. Prep HPLC, mass guided purification system, semi-prep chiral HPLC, and other purification lab equipment
Computational Chemistry:
The use of cutting-edge techniques and intelligent drug design has aided in the identification of advanced leads. Hit to Lead identification may be made more efficient with smart design and enhanced in-silico screening procedures.
- Fragment-based drug discovery, homology modelling, and molecular docking
- Quantitative structure Relationship activity (QSAR)
- Core hopping and pharmacophore modelling
- Screening with a virtual high throughput (vHTS)
- Designing a diverse library with a focus on the target audience
- To create a high-quality SAR, different data sources are combined.
- Physicochemical characteristics are calculated.
- MOE and GOLD are two software packages.
Analytical Chemistry:
Purification and structural elucidation of produced compounds and impurities are supported by a professional team with competence in handling advanced technology.
- Purity analysis employing advanced detection systems such as HPLC & UPLC with PDA, UV, ELSD, RI, LC-MS/MS with UPLC, PDA, ELSD, LC-MS/MS with UPLC, PDA, ELSD, LC-MS/MS with UPLC, PDA, ELSD, LC-MS/MS with UPLC, PDA, EL
- Development of chiral and achiral analytical methods and purification of chiral and achiral substances on a milligramme to multigram scale
- Studies on stability and degradation
- DSC Analytical apparatus for polymorph detection includes 400MHz NMR, LC-MS, HPLC, GC, GCMS, Prep HPLC, Mass Directed Purifications System, and SFC.